Skin lightening (melasma, dark spots)

Hydroquinone cream

Hydroquinone (topical)

Hydroquinone is a cosmetic ingredient rather than a medicine in Japan: 1–2% products are sold in drugstores and online, and cosmetic dermatology clinics provide 4–5% creams, often with tretinoin. For melasma, Japanese dermatologists also use oral tranexamic acid, which is unusual abroad.

At a glance
Prescription status
Not approved in Japan
Over the counter
Not sold OTC
Bringing it into Japan
✓ 1 month Rx / 2 months OTC
Names abroad
Tri-Luma (combination) · 멜라논

Over the counter

Not approved as a medicine. Low concentrations (about 2%) are sold as cosmetics in Japan; 4–5% creams are dispensed by cosmetic clinics at full cost.

Prescription products in Japan

0 products

Products on Japan's national drug price list. Prescription only: a clinic visit is needed, and pharmacies may substitute a generic with the same ingredient.

Dosage forms

Product names are shown in Japanese, exactly as printed on the package and the prescription. Show this page at the pharmacy.

All listed products (0) · Drug price list as of 2026-08-12

Bringing it into Japan

Not approved in Japan, so it cannot be prescribed or bought here. Bringing your own supply for personal use follows the normal rule: up to 1 month of prescription medicine without paperwork.

How to apply for a Yakkan Shoumei (article)

Names abroad

USTri-Luma (combination), Hydroquinone 4%
Korea멜라논, 도미나크림
China千白
Taiwan對苯二酚藥膏

Sources

  1. Health Insurance Claims Review & Reimbursement Services — Drug master (NHI drug price list) shinryohoshu.mhlw.go.jp — 2026-08-12
  2. Ministry of Health, Labour and Welfare — Bringing medicines for personal use into Japan mhlw.go.jp

This page describes how a medicine is regulated and sold in Japan. It is not medical advice and does not cover dosing for your situation; follow your doctor's and pharmacist's instructions.