Acne retinoid (topical)

Adapalene (Differin)

Adapalene · ディフェリン

Adapalene (Differin gel 0.1%) with benzoyl peroxide (Bepio) and their combination Epiduo form the core of insured acne treatment in Japan. All are prescription-only; expect a dermatology visit plus the gel to cost a few thousand yen without insurance.

At a glance
Prescription status
Prescription only
Over the counter
Not sold OTC
Bringing it into Japan
✓ 1 month Rx / 2 months OTC
Names abroad
Differin

Over the counter

Prescription only in Japan, unlike the OTC Differin sold in the US. Dermatology visits are cheap with insurance, and any dermatologist prescribes it.

Prescription products in Japan

12 products

Products on Japan's national drug price list. Prescription only: a clinic visit is needed, and pharmacies may substitute a generic with the same ingredient.

Brand namesディフェリン
Generic11 generic products
Dosage formsTopical

Product names are shown in Japanese, exactly as printed on the package and the prescription. Show this page at the pharmacy.

All listed products (12) · Drug price list as of 2026-08-12
ディフェリンゲル0.1%Topical · ¥40.1/g
アダパレンクリーム0.1%「ニプロ」 · GenericTopical · ¥17.9/g
アダパレンゲル0.1%「JG」 · GenericTopical · ¥17.9/g
アダパレンゲル0.1%「KMP」 · GenericTopical · ¥17.9/g
アダパレンゲル0.1%「TCK」 · GenericTopical · ¥21.2/g
アダパレンゲル0.1%「YD」 · GenericTopical · ¥17.9/g
アダパレンゲル0.1%「イワキ」 · GenericTopical · ¥21.2/g
アダパレンゲル0.1%「テイコク」 · GenericTopical · ¥17.9/g
アダパレンゲル0.1%「ニットー」 · GenericTopical · ¥17.9/g
アダパレンゲル0.1%「ニプロ」 · GenericTopical · ¥17.9/g
アダパレンゲル0.1%「日新」 · GenericTopical · ¥21.2/g
アダパレンゲル0.1%「東光」 · GenericTopical · ¥17.9/g

Bringing it into Japan

Up to a 1-month supply of prescription medicine, or 2 months of OTC medicine, without any paperwork. For more, apply for a Yakkan Shoumei (import confirmation) before travel.

How to apply for a Yakkan Shoumei (article)

Getting it prescribed in Japan

Any clinic can prescribe it after a consultation. Bring the original packaging or a medication list. Use the hospital finder to find clinics with English-speaking staff or an international patient office.

Find a clinic by language

Names abroad

USDifferin
UKDifferin
Korea디페린
China达芙文
Taiwan痘膚潤

Sources

  1. Health Insurance Claims Review & Reimbursement Services — Drug master (NHI drug price list) shinryohoshu.mhlw.go.jp — 2026-08-12
  2. Ministry of Health, Labour and Welfare — Bringing medicines for personal use into Japan mhlw.go.jp

This page describes how a medicine is regulated and sold in Japan. It is not medical advice and does not cover dosing for your situation; follow your doctor's and pharmacist's instructions.