Menopause hormone therapy

Estradiol (HRT: Estrana, Climara)

Estradiol (HRT patch, gel, tablet) · エストラーナ · ディビ · ル・エストロジェル

Japan favors transdermal estradiol for menopause: Estrana patches (changed every 2 days), L'Estrogel and Divigel gels, and the combined Menoaid patch with norethisterone. Oral estradiol (Julina) also exists. HRT is prescribed by gynecologists and covered by insurance, though uptake is lower than in the West.

At a glance
Prescription status
Prescription only
Over the counter
Not sold OTC
Bringing it into Japan
✓ 1 month Rx / 2 months OTC
Names abroad
Climara · Evorel

Over the counter

Prescription only, covered by insurance for menopausal symptoms.

Prescription products in Japan

6 products

Products on Japan's national drug price list. Prescription only: a clinic visit is needed, and pharmacies may substitute a generic with the same ingredient.

Brand namesエストラーナ · ディビ · ル・エストロジェル
Dosage formsTopical

Product names are shown in Japanese, exactly as printed on the package and the prescription. Show this page at the pharmacy.

All listed products (6) · Drug price list as of 2026-08-12
エストラーナテープ0.09mg 1.125cm2Topical · ¥86.5/sheet
エストラーナテープ0.18mg 2.25cm2Topical · ¥125.9/sheet
エストラーナテープ0.36mg 4.5cm2Topical · ¥45/sheet
エストラーナテープ0.72mg 9cm2Topical · ¥66.1/sheet
ディビゲル1mgTopical · ¥34.3/packet
ル・エストロジェル0.06%Topical · ¥19.1/g

Bringing it into Japan

Up to a 1-month supply of prescription medicine, or 2 months of OTC medicine, without any paperwork. For more, apply for a Yakkan Shoumei (import confirmation) before travel.

How to apply for a Yakkan Shoumei (article)

Getting it prescribed in Japan

Any clinic can prescribe it after a consultation. Bring the original packaging or a medication list. Use the hospital finder to find clinics with English-speaking staff or an international patient office.

Find a clinic by language

Names abroad

USClimara, Vivelle-Dot, Estrace
UKEvorel, Oestrogel, Elleste
Korea에스트라디올 패치
China补佳乐
Taiwan雌二醇貼片

Sources

  1. Health Insurance Claims Review & Reimbursement Services — Drug master (NHI drug price list) shinryohoshu.mhlw.go.jp — 2026-08-12
  2. Ministry of Health, Labour and Welfare — Bringing medicines for personal use into Japan mhlw.go.jp

This page describes how a medicine is regulated and sold in Japan. It is not medical advice and does not cover dosing for your situation; follow your doctor's and pharmacist's instructions.