Proton pump inhibitor (acid reducer)

Esomeprazole

Esomeprazole · ネキシウム

Esomeprazole (Nexium) is a proton pump inhibitor for reflux, gastric ulcers and H. pylori eradication. In Japan it is prescription-only, in 10 mg and 20 mg capsules and granules. Nexium 24HR, the OTC version sold in the US, is not available.

At a glance
Prescription status
Prescription only
Over the counter
Not sold OTC
Bringing it into Japan
✓ 1 month Rx / 2 months OTC
Names abroad
Nexium

Over the counter

No proton pump inhibitor is sold OTC in Japan. The OTC alternative for heartburn is the H2 blocker famotidine (Gaster 10, Class 1).

Prescription products in Japan

20 products

Products on Japan's national drug price list. Prescription only: a clinic visit is needed, and pharmacies may substitute a generic with the same ingredient.

Brand namesネキシウム
Generic16 generic products
Dosage formsOral
Strengths (oral)10mg · 20mg
Official price (per tablet or unit)¥19.4 – ¥70.4
Official NHI drug price. Patients with Japanese insurance pay 10–30%; visitors without it pay the full price plus consultation fees.

Product names are shown in Japanese, exactly as printed on the package and the prescription. Show this page at the pharmacy.

All listed products (20) · Drug price list as of 2026-08-12
ネキシウムカプセル10mgOral · ¥27.2/capsule
ネキシウムカプセル20mgOral · ¥48.2/capsule
ネキシウム懸濁用顆粒分包10mgOral · ¥39.1/packet
ネキシウム懸濁用顆粒分包20mgOral · ¥70.4/packet
エソメプラゾールカプセル10mg「DSEP」 · GenericOral · ¥19.4/capsule
エソメプラゾールカプセル10mg「YD」 · GenericOral · ¥19.4/capsule
エソメプラゾールカプセル10mg「ケミファ」 · GenericOral · ¥19.4/capsule
エソメプラゾールカプセル10mg「サワイ」 · GenericOral · ¥19.4/capsule
エソメプラゾールカプセル10mg「トーワ」 · GenericOral · ¥19.4/capsule
エソメプラゾールカプセル10mg「ニプロ」 · GenericOral · ¥19.4/capsule
エソメプラゾールカプセル10mg「日新」 · GenericOral · ¥19.4/capsule
エソメプラゾールカプセル10mg「杏林」 · GenericOral · ¥19.4/capsule
エソメプラゾールカプセル20mg「DSEP」 · GenericOral · ¥33.7/capsule
エソメプラゾールカプセル20mg「YD」 · GenericOral · ¥33.7/capsule
エソメプラゾールカプセル20mg「ケミファ」 · GenericOral · ¥33.7/capsule
エソメプラゾールカプセル20mg「サワイ」 · GenericOral · ¥33.7/capsule
エソメプラゾールカプセル20mg「トーワ」 · GenericOral · ¥33.7/capsule
エソメプラゾールカプセル20mg「ニプロ」 · GenericOral · ¥33.7/capsule
エソメプラゾールカプセル20mg「日新」 · GenericOral · ¥33.7/capsule
エソメプラゾールカプセル20mg「杏林」 · GenericOral · ¥33.7/capsule

Bringing it into Japan

Up to a 1-month supply of prescription medicine, or 2 months of OTC medicine, without any paperwork. For more, apply for a Yakkan Shoumei (import confirmation) before travel.

How to apply for a Yakkan Shoumei (article)

Getting it prescribed in Japan

Any clinic can prescribe it after a consultation. Bring the original packaging or a medication list. Use the hospital finder to find clinics with English-speaking staff or an international patient office.

Find a clinic by language

Names abroad

USNexium
UKNexium
Korea넥시움
China耐信
Taiwan耐適恩

Frequently asked questions (FAQ)

I take Nexium daily. What if I run out in Japan?

See a doctor at a clinic; esomeprazole is prescribed routinely. Bring your medication list. Without Japanese insurance you pay the full cost, usually a few thousand yen for the visit plus the drug.

Sources

  1. Health Insurance Claims Review & Reimbursement Services — Drug master (NHI drug price list) shinryohoshu.mhlw.go.jp — 2026-08-12
  2. Ministry of Health, Labour and Welfare — Bringing medicines for personal use into Japan mhlw.go.jp

This page describes how a medicine is regulated and sold in Japan. It is not medical advice and does not cover dosing for your situation; follow your doctor's and pharmacist's instructions.