Antiepileptic / Parkinson's

Zonisamide (Zonegran)

Zonisamide · エクセグラン

Zonisamide was discovered in Japan and is sold here as Excegran for epilepsy and, at low dose as Trerief, for Parkinson's disease, a use approved only in Japan. Prescription-only and not controlled.

At a glance
Prescription status
Prescription only
Over the counter
Not sold OTC
Bringing it into Japan
✓ 1 month Rx / 2 months OTC
Names abroad
Zonegran

Over the counter

Prescription only.

Prescription products in Japan

6 products

Products on Japan's national drug price list. Prescription only: a clinic visit is needed, and pharmacies may substitute a generic with the same ingredient.

Brand namesエクセグラン
Generic4 generic products
Dosage formsOral
Strengths (oral)100mg
Official price (per tablet or unit)¥10.8 – ¥25.2
Official NHI drug price. Patients with Japanese insurance pay 10–30%; visitors without it pay the full price plus consultation fees.

Product names are shown in Japanese, exactly as printed on the package and the prescription. Show this page at the pharmacy.

All listed products (6) · Drug price list as of 2026-08-12
エクセグラン散20%Oral · ¥25.2/g
エクセグラン錠100mgOral · ¥12.6/tablet
ゾニサミド100mg錠 · GenericOral · ¥10.8/tablet
ゾニサミド散20%「アメル」 · GenericOral · ¥23.8/g
ゾニサミド錠100mgEX「KO」 · GenericOral · ¥10.8/tablet
ゾニサミド錠100mg「アメル」 · GenericOral · ¥10.8/tablet

Bringing it into Japan

Up to a 1-month supply of prescription medicine, or 2 months of OTC medicine, without any paperwork. For more, apply for a Yakkan Shoumei (import confirmation) before travel.

How to apply for a Yakkan Shoumei (article)

Getting it prescribed in Japan

Any clinic can prescribe it after a consultation. Bring the original packaging or a medication list. Use the hospital finder to find clinics with English-speaking staff or an international patient office.

Find a clinic by language

Names abroad

USZonegran
UKZonegran
Korea조네그란
China唑尼沙胺
Taiwan唑尼沙胺

Sources

  1. Health Insurance Claims Review & Reimbursement Services — Drug master (NHI drug price list) shinryohoshu.mhlw.go.jp — 2026-08-12
  2. Ministry of Health, Labour and Welfare — Bringing medicines for personal use into Japan mhlw.go.jp

This page describes how a medicine is regulated and sold in Japan. It is not medical advice and does not cover dosing for your situation; follow your doctor's and pharmacist's instructions.